Enteroendocrine L cell: difference between revisions
Diff·revision 12 → 13·07:07, 28 Jan 2025
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| Revision 12 — 11:02, 9 Jan 2025 IncretinIvo (talk) expand §GLP-1 synthesis and secretion 4,107 bytes +641 | Revision 13 — 07:07, 28 Jan 2025 ColumnOvenCoy (talk) space between number and unit per PP:MOS 4,619 bytes +512 | ||
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| 18 | L-cell mass increases in response to elevated nutrient load, particularly in the weeks following bariatric surgery, indicating L cells are responsive to systemic metabolic signals.{{r|creutzfeldt1979}} Animal studies show that genetically obese mice have altered L-cell GLP-1 content and secretory response to nutrient stimuli; however, the corresponding relationship in humans remains incompletely characterised.{{r|furness2013}} | 18 | L-cell mass increases in response to elevated nutrient load, particularly in the weeks following bariatric surgery, indicating L cells are responsive to systemic metabolic signals.{{r|creutzfeldt1979}} Animal studies show that genetically obese mice have altered L-cell GLP-1 content and secretory response to nutrient stimuli; however, the corresponding relationship in humans remains incompletely characterised.{{r|furness2013}} |
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| + | 20 | L cells are continuously regenerated from intestinal stem cells in the intestinal crypts, with a typical lifespan of 3–5 days for a mature L cell. Factors influencing L-cell differentiation include specific transcription-factor pathways, growth factors from neighbouring cells, and signalling molecules from the microbiota.{{r|biemin2019}} | |
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| 20 | == References == | 22 | == References == |
| 21 | {{reflist}} | 23 | {{reflist}} |
| 22 | <ref name="holst2007">Holst JJ. "The physiology of glucagon-like peptide 1." ''Physiological Reviews'' 87(4):1409–1439 (2007). DOI:10.1152/physrev.00034.2006. PMID 17928588.</ref> | 24 | <ref name="holst2007">Holst JJ. "The physiology of glucagon-like peptide 1." ''Physiological Reviews'' 87(4):1409–1439 (2007). DOI:10.1152/physrev.00034.2006. PMID 17928588.</ref> |
| 23 | <ref name="furness2013">Furness JB, Rivera LR, Cho H-J, Bravo DM, Callaghan B. "The gut as a sensory organ." ''Nature Reviews Gastroenterology & Hepatology'' 10(12):729–740 (2013). DOI:10.1038/nrgastro.2013.180. PMID 24061205.</ref> | 25 | <ref name="furness2013">Furness JB, Rivera LR, Cho H-J, Bravo DM, Callaghan B. "The gut as a sensory organ." ''Nature Reviews Gastroenterology & Hepatology'' 10(12):729–740 (2013). DOI:10.1038/nrgastro.2013.180. PMID 24061205.</ref> |
| + | 26 | <ref name="biemin2019">Campbell JE, Drucker DJ. "Pharmacology, physiology, and mechanisms of incretin hormone action." ''Cell Metabolism'' 17(6):819–837 (2013).</ref> | |
| 24 | <ref name="creutzfeldt1979">Creutzfeldt W, Ebert R, Willms B. "Gastro-intestinal peptide hormones and insulin secretion." ''Diabetologia'' 20 Suppl:85–98 (1979).</ref> | 27 | <ref name="creutzfeldt1979">Creutzfeldt W, Ebert R, Willms B. "Gastro-intestinal peptide hormones and insulin secretion." ''Diabetologia'' 20 Suppl:85–98 (1979).</ref> |
| 25 | 28 |