Glucose-dependent insulinotropic polypeptide: difference between revisions
Diff·revision 14 → 15·16:47, 7 Feb 2025
Difference between revision 14 and revision 15 of Glucose-dependent insulinotropic polypeptide. 2 lines changed; the page grew by 455 bytes.
| Revision 14 — 13:24, 10 Jan 2025 IncretinIvo (talk) correct the direction of the effect on gastric emptying 6,231 bytes ±0 | Revision 15 — 16:47, 7 Feb 2025 DPP4_Dagmar (talk) ce, tighten prose 6,686 bytes +455 | ||
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| 39 | In type 2 diabetes, the incretin effect is attenuated primarily because beta cells are unresponsive to GIP — even pharmacological GIP concentrations fail to stimulate insulin secretion, whereas GLP-1-directed drugs remain effective. This loss of GIP potency has been termed ''GIP-incompetence'' and is distinct from deficient GIP secretion, which does not occur. The mechanism remains unclear; current hypotheses include altered receptor expression, impaired downstream signalling and altered beta-cell function secondary to chronic hyperglycaemia.{{r|nauck2019}} | 39 | In type 2 diabetes, the incretin effect is attenuated primarily because beta cells are unresponsive to GIP — even pharmacological GIP concentrations fail to stimulate insulin secretion, whereas GLP-1-directed drugs remain effective. This loss of GIP potency has been termed ''GIP-incompetence'' and is distinct from deficient GIP secretion, which does not occur. The mechanism remains unclear; current hypotheses include altered receptor expression, impaired downstream signalling and altered beta-cell function secondary to chronic hyperglycaemia.{{r|nauck2019}} |
| 40 | 40 | ||
| + | 41 | In obesity without diabetes, fasting GIP is elevated and the postprandial response is exaggerated, particularly to fat ingestion. Whether this hyperresponse contributes to weight gain or is a consequence of it remains unresolved. The observation that dual GIP/GLP-1 agonists produce greater weight loss than GLP-1 monotherapy is sometimes attributed to active GIP-receptor antagonism at the adipocyte, though the evidence remains limited.{{r|frias2021}} | |
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| 41 | == References == | 43 | == References == |
| 42 | {{reflist}} | 44 | {{reflist}} |