Karl Fischer titration: difference between revisions
Diff·revision 10 → 11·15:40, 28 Oct 2024
Difference between revision 10 and revision 11 of Karl Fischer titration. 1 line changed; the page grew by 155 bytes.
| Revision 10 — 07:55, 13 Oct 2024 Chromatokid (talk) expand §Chemical basis 4,811 bytes +330 | Revision 11 — 15:40, 28 Oct 2024 IncretinIvo (talk) convert a hard-coded date to the house format 4,966 bytes +155 | ||
|---|---|---|---|
| 12 | | Sample size = 10–100 mg lyophilised solid | 12 | | Sample size = 10–100 mg lyophilised solid |
| 13 | }} | 13 | }} |
| + | 14 | {{hatnote|For the alternative gravimetric approach, see [[Loss on drying]]. For what water content implies about vial contents, see [[Peptide content]].}} | |
| 14 | 15 | ||
| 15 | '''Karl Fischer titration''' is a titrimetric method for determining the water content of a sample, based on the stoichiometric oxidation of sulfur dioxide by iodine in the presence of water. It is the reference technique for moisture determination in lyophilised pharmaceutical solids and is specified in pharmacopoeial moisture chapters worldwide — USP <921> and Ph. Eur. 2.5.12.{{r|usp921}} | 16 | '''Karl Fischer titration''' is a titrimetric method for determining the water content of a sample, based on the stoichiometric oxidation of sulfur dioxide by iodine in the presence of water. It is the reference technique for moisture determination in lyophilised pharmaceutical solids and is specified in pharmacopoeial moisture chapters worldwide — USP <921> and Ph. Eur. 2.5.12.{{r|usp921}} |