Multi-dose vial: difference between revisions
Diff·revision 14 → 15·21:56, 30 Jul 2025
Difference between revision 14 and revision 15 of Multi-dose vial. 2 lines changed; the page grew by 146 bytes.
| Revision 14 — 19:46, 13 Jul 2025 BUD_Bertram (talk) British spelling per PP:MOS 18,051 bytes +1,490 | Revision 15 — 21:56, 30 Jul 2025 ImportPolicyIggy (talk) expand §Definition and compendial basis 18,197 bytes +146 | ||
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| 97 | Surface disinfection before each entry is the practice measure addressed at the other end of the problem. Once a flip-off button is removed, the exposed face of the closure is a surface like any other, and guidance expects it to be disinfected with an appropriate agent and allowed to dry before each penetration. Studies of contamination of vial closures in clinical use have found organisms recoverable from a proportion of them, which is the empirical basis for the practice.{{r|mattner2004,cdc_injection}} | 97 | Surface disinfection before each entry is the practice measure addressed at the other end of the problem. Once a flip-off button is removed, the exposed face of the closure is a surface like any other, and guidance expects it to be disinfected with an appropriate agent and allowed to dry before each penetration. Studies of contamination of vial closures in clinical use have found organisms recoverable from a proportion of them, which is the empirical basis for the practice.{{r|mattner2004,cdc_injection}} |
| 98 | 98 | ||
| + | 99 | {{figure|vial|The closure is the only part of the container that is deliberately breached, and it is breached repeatedly in multiple-dose use.}} | |
| + | 100 | ||
| 99 | == Documented infection events == | 101 | == Documented infection events == |
| 100 | The literature on infection associated with multiple-dose vials divides into two classes, and the distinction matters because the mechanisms and the remedies differ. | 102 | The literature on infection associated with multiple-dose vials divides into two classes, and the distinction matters because the mechanisms and the remedies differ. |