Peptide stability table: difference between revisions
Diff·revision 13 → 14·12:46, 10 May 2025
Difference between revision 13 and revision 14 of Peptide stability table. 8 lines changed; the page grew by 847 bytes.
| Revision 13 — 00:12, 26 Apr 2025 EscalationEira (talk) expand §Why cross-source comparison is unsafe 4,044 bytes +26 | Revision 14 — 12:46, 10 May 2025 DisclosureDido (talk) move a stray full stop inside the reference 4,891 bytes +847 | ||
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| 11 | | Not covered = Sterility, endotoxin, container-closure integrity | 11 | | Not covered = Sterility, endotoxin, container-closure integrity |
| 12 | }} | 12 | }} |
| + | 13 | {{primarysources|date=September 2025|talk=Sourcing of the reconstituted-stability column}} | |
| 13 | 14 | ||
| 14 | The '''peptide stability table''' collects reported storage conditions and stability intervals for compounds covered on this wiki. It is a navigational and comparative aid rather than a source in its own right: every figure in it is attributable to labelling or to a published study, and the two are not equivalent evidence. | 15 | The '''peptide stability table''' collects reported storage conditions and stability intervals for compounds covered on this wiki. It is a navigational and comparative aid rather than a source in its own right: every figure in it is attributable to labelling or to a published study, and the two are not equivalent evidence. |
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| 30 | {{note|An interval is not a cliff. A 28-day figure means the formulation was shown to remain within specification for 28 days under the stated conditions; it does not mean the material is inert on day 27 and unusable on day 29, nor that it was ever tested on day 40.}} | 31 | {{note|An interval is not a cliff. A 28-day figure means the formulation was shown to remain within specification for 28 days under the stated conditions; it does not mean the material is inert on day 27 and unusable on day 29, nor that it was ever tested on day 40.}} |
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| + | 33 | == Why cross-source comparison is unsafe == | |
| + | 34 | Four differences between sources make two stability figures incomparable even when both are honestly reported. | |
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| + | 36 | '''The specification differs.''' "Stable for 28 days" means "remained within the specification" and specifications differ. A limit of 95% of label potency and a limit of 90% produce different intervals from identical data. | |
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| + | 38 | '''The assay differs.''' A stability-indicating [[High-performance liquid chromatography|HPLC]] method that resolves the principal degradant reports loss that a method which co-elutes it does not. [[Analytical method validation|Method validation]] is what establishes that a method is stability-indicating, and research-compound figures rarely state whether it was.{{r|ich}} | |
| 31 | 39 | ||
| 32 | == References == | 40 | == References == |