Reconstitution calculator: difference between revisions
Diff·revision 17 → 18·11:34, 2 Jul 2025
Difference between revision 17 and revision 18 of Reconstitution calculator. 5 lines changed; the page grew by 336 bytes.
| Revision 17 — 07:41, 7 Jun 2025 DeletionDeb (talk) the calculator rounded before dividing; corrected 7,305 bytes +325 | Revision 18 — 11:34, 2 Jul 2025 ResolutionRoo (talk) give the figures to a consistent number of significant figures 7,641 bytes +336 | ||
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| 65 | '''Dead space.''' Volume retained in the syringe hub and needle after the plunger is fully depressed is not delivered. Reported figures range from roughly 0.02 mL for a low-dead-space insulin syringe with a fixed needle to 0.07 mL or more for a detachable-needle arrangement.{{r|whodeadspace}} Against a 0.10 mL dose that is a 20–70% loss if the syringe is not primed, which is why the dead-space field exists: entering a figure shows its effect on the number of doses the vial yields, not on the delivered dose, since a primed syringe delivers its nominal volume. | 65 | '''Dead space.''' Volume retained in the syringe hub and needle after the plunger is fully depressed is not delivered. Reported figures range from roughly 0.02 mL for a low-dead-space insulin syringe with a fixed needle to 0.07 mL or more for a detachable-needle arrangement.{{r|whodeadspace}} Against a 0.10 mL dose that is a 20–70% loss if the syringe is not primed, which is why the dead-space field exists: entering a figure shows its effect on the number of doses the vial yields, not on the delivered dose, since a primed syringe delivers its nominal volume. |
| 66 | 66 | ||
| + | 67 | {{figure|syringe|Graduations on a 1 mL U-100 barrel. The scale reads volume; the mass it corresponds to depends entirely on the concentration in the vial.}} | |
| + | 68 | ||
| 67 | == References == | 69 | == References == |
| 68 | {{reflist}} | 70 | {{reflist}} |
| ⋮ | ⋮ | ||
| 71 | <ref name="iso7886">ISO 7886-1, ''Sterile hypodermic syringes for single use — Part 1: Syringes for manual use''. International Organization for Standardization.</ref> | 73 | <ref name="iso7886">ISO 7886-1, ''Sterile hypodermic syringes for single use — Part 1: Syringes for manual use''. International Organization for Standardization.</ref> |
| 72 | <ref name="whodeadspace">World Health Organization, ''WHO Guideline on the Use of Safety-Engineered Syringes'' (2015) — includes dead-space characterisation of syringe types.</ref> | 74 | <ref name="whodeadspace">World Health Organization, ''WHO Guideline on the Use of Safety-Engineered Syringes'' (2015) — includes dead-space characterisation of syringe types.</ref> |
| + | 75 | ||
| + | 76 | == Further reading == | |
| + | 77 | * International Council for Harmonisation, ''Q6A: Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products''. | |
| 73 | 78 | ||
| 74 | == See also == | 79 | == See also == |