Reconstitution calculator: difference between revisions
Diff·revision 8 → 9·02:14, 21 Dec 2024
Difference between revision 8 and revision 9 of Reconstitution calculator. 4 lines changed; the page grew by 761 bytes.
| Revision 8 — 03:39, 26 Nov 2024 SourceHunterSile (talk) copyedit 3,369 bytes ±0 | Revision 9 — 02:14, 21 Dec 2024 TalkPageTaro (talk) expand §The calculator 4,130 bytes +761 | ||
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| 11 | | Assumption = Negligible volume displacement by the solid | 11 | | Assumption = Negligible volume displacement by the solid |
| 12 | }} | 12 | }} |
| + | 13 | {{hatnote|For the underlying procedure and its sources, see [[Reconstitution of lyophilised peptides]]. For the syringe scales, see [[Insulin syringe unit conversion]].}} | |
| 13 | 14 | ||
| 14 | The '''reconstitution calculator''' relates the four quantities involved in dissolving a lyophilised peptide and drawing a dose from it: the mass of solid in the vial, the volume of diluent added, the intended dose, and the reading on the syringe barrel. All four are connected by one division, and almost every error reported in the literature and in community accounts is a confusion between two of them rather than a failure of the arithmetic itself.{{r|usp797}} | 15 | The '''reconstitution calculator''' relates the four quantities involved in dissolving a lyophilised peptide and drawing a dose from it: the mass of solid in the vial, the volume of diluent added, the intended dose, and the reading on the syringe barrel. All four are connected by one division, and almost every error reported in the literature and in community accounts is a confusion between two of them rather than a failure of the arithmetic itself.{{r|usp797}} |
| ⋮ | ⋮ | ||
| 37 | The last row illustrates the most common unit confusion: a dose expressed in micrograms against a concentration expressed in milligrams per millilitre. One thousand micrograms is one milligram, so 100 µg of a 1 mg/mL solution is 0.1 mL — ten units on a U-100 syringe, not one hundred. | 38 | The last row illustrates the most common unit confusion: a dose expressed in micrograms against a concentration expressed in milligrams per millilitre. One thousand micrograms is one milligram, so 100 µg of a 1 mg/mL solution is 0.1 mL — ten units on a U-100 syringe, not one hundred. |
| 38 | 39 | ||
| + | 40 | Two rows are worth noticing for a different reason. A 150-unit dose does not fit in a 1 mL insulin syringe, and the tool warns when a computed volume exceeds a plausible barrel. A 5-unit dose sits at the very bottom of a U-100 barrel, where the graduation interval is a large fraction of the dose and precision is correspondingly poor; a lower concentration would place the same dose further up the scale.{{r|iso7886}} | |
| + | 41 | ||
| 39 | == References == | 42 | == References == |
| 40 | {{reflist}} | 43 | {{reflist}} |
| 41 | <ref name="usp797">United States Pharmacopeia, General Chapter <797>, "Pharmaceutical Compounding — Sterile Preparations". USP–NF, current revision.</ref> | 44 | <ref name="usp797">United States Pharmacopeia, General Chapter <797>, "Pharmaceutical Compounding — Sterile Preparations". USP–NF, current revision.</ref> |
| + | 45 | <ref name="iso7886">ISO 7886-1, ''Sterile hypodermic syringes for single use — Part 1: Syringes for manual use''. International Organization for Standardization.</ref> | |
| 42 | 46 | ||
| 43 | {{DEFAULTSORT:Reconstitution calculator}} | 47 | {{DEFAULTSORT:Reconstitution calculator}} |