Trial data comparison: difference between revisions
Diff·revision 14 → 15·16:36, 26 May 2025
Difference between revision 14 and revision 15 of Trial data comparison. 5 lines changed; the page grew by 570 bytes.
| Revision 14 — 05:50, 9 May 2025 Ref_Desk_Ron (talk) state the rounding rule the readout uses 4,355 bytes ±0 | Revision 15 — 16:36, 26 May 2025 MarginNoteMars (talk) state the diluent volume the default assumes 4,925 bytes +570 | ||
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| 12 | }} | 12 | }} |
| 13 | {{hatnote|For the programmes themselves, see [[STEP trial programme]], [[SURMOUNT trial programme]], [[SURPASS trial programme]] and [[TRIUMPH trial programme]].}} | 13 | {{hatnote|For the programmes themselves, see [[STEP trial programme]], [[SURMOUNT trial programme]], [[SURPASS trial programme]] and [[TRIUMPH trial programme]].}} |
| + | 14 | {{refimprove|date=May 2026|talk=Cross-trial tabulation and the estimand problem}} | |
| 14 | 15 | ||
| 15 | The '''trial data comparison''' tabulates the principal published results of the major randomised trials of [[GLP-1 receptor agonist|GLP-1 receptor agonists]] and related compounds, so that a reader arriving at one figure can see the others alongside it. Each row is attributed to its trial, arm, duration and comparator. | 16 | The '''trial data comparison''' tabulates the principal published results of the major randomised trials of [[GLP-1 receptor agonist|GLP-1 receptor agonists]] and related compounds, so that a reader arriving at one figure can see the others alongside it. Each row is attributed to its trial, arm, duration and comparator. |
| ⋮ | ⋮ | ||
| 40 | | Not stated | — | Unusable for comparison | | 41 | | Not stated | — | Unusable for comparison | |
| 41 | 42 | ||
| + | 43 | The SURMOUNT programme's publications state their estimand explicitly, which is why the tirzepatide rows in the table above can be compared with each other with more confidence than the cross-programme rows can.{{r|surmount1}} | |
| + | 44 | ||
| 42 | == References == | 45 | == References == |
| 43 | {{reflist}} | 46 | {{reflist}} |
| ⋮ | ⋮ | ||
| 45 | <ref name="step1">Wilding JPH, Batterham RL, Calanna S, et al. "Once-Weekly Semaglutide in Adults with Overweight or Obesity." ''New England Journal of Medicine'' 384(11):989–1002 (2021). DOI:10.1056/NEJMoa2032183. PMID 33567185.</ref> | 48 | <ref name="step1">Wilding JPH, Batterham RL, Calanna S, et al. "Once-Weekly Semaglutide in Adults with Overweight or Obesity." ''New England Journal of Medicine'' 384(11):989–1002 (2021). DOI:10.1056/NEJMoa2032183. PMID 33567185.</ref> |
| 46 | <ref name="surpass2">Frías JP, Davies MJ, Rosenstock J, et al. "Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes." ''New England Journal of Medicine'' 385(6):503–515 (2021). DOI:10.1056/NEJMoa2107519. PMID 34170647.</ref> | 49 | <ref name="surpass2">Frías JP, Davies MJ, Rosenstock J, et al. "Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes." ''New England Journal of Medicine'' 385(6):503–515 (2021). DOI:10.1056/NEJMoa2107519. PMID 34170647.</ref> |
| + | 50 | <ref name="surmount1">Jastreboff AM, Aronne LJ, Ahmad NN, et al. "Tirzepatide Once Weekly for the Treatment of Obesity." ''New England Journal of Medicine'' 387(3):205–216 (2022). DOI:10.1056/NEJMoa2206038. PMID 35658024.</ref> | |
| 47 | 51 | ||
| 48 | == See also == | 52 | == See also == |
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| 52 | * [[SELECT trial]] | 56 | * [[SELECT trial]] |
| 53 | * [[Intention-to-treat analysis]] | 57 | * [[Intention-to-treat analysis]] |
| + | 58 | * [[Placebo-adjusted effect]] | |
| 54 | 59 | ||
| 55 | {{DEFAULTSORT:Trial data comparison}} | 60 | {{DEFAULTSORT:Trial data comparison}} |