Vial: difference between revisions
Diff·revision 15 → 16·17:34, 13 Feb 2025
Difference between revision 15 and revision 16 of Vial. 3 lines changed; the page grew by 597 bytes.
| Revision 15 — 07:28, 30 Jan 2025 FiveOhThreeB (talk) the article confused primary and secondary drying; corrected 17,132 bytes +1,080 | Revision 16 — 17:34, 13 Feb 2025 Chromatokid (talk) give the vial sizes in millilitres of nominal capacity 17,729 bytes +597 | ||
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| 118 | The mechanical figure of merit is ''residual seal force'': the compressive force remaining on the stopper after crimping and after the elastomer has relaxed. Too little leaves an unreliable seal; too much can distort the stopper, damage the glass sealing surface or crack the flange. Residual seal force is measurable non-destructively and has become the conventional in-process control for capping, replacing subjective assessments such as attempting to rotate the cap by hand.{{r|kirsch1997,usp1207}} | 118 | The mechanical figure of merit is ''residual seal force'': the compressive force remaining on the stopper after crimping and after the elastomer has relaxed. Too little leaves an unreliable seal; too much can distort the stopper, damage the glass sealing surface or crack the flange. Residual seal force is measurable non-destructively and has become the conventional in-process control for capping, replacing subjective assessments such as attempting to rotate the cap by hand.{{r|kirsch1997,usp1207}} |
| 119 | 119 | ||
| + | 120 | Ferrule designs differ in how the closure is later opened. A plain ferrule fully covers the stopper and must be removed with a decapping tool. A flip-off design carries a plastic button over a pre-cut aperture, which is lifted away to expose the central area of the stopper for needle penetration while leaving the crimp intact — the arrangement almost universal for injectable products and for research peptide vials. Colour of the button is a manufacturer's identification device with no standardised meaning, and it is not a reliable indicator of contents.{{r|iso8362_5}} | |
| + | 121 | ||
| 120 | == References == | 122 | == References == |
| 121 | {{reflist}} | 123 | {{reflist}} |
| ⋮ | ⋮ | ||
| 141 | * [[Beyond-use date]] | 143 | * [[Beyond-use date]] |
| 142 | * [[Reconstitution of lyophilised peptides]] | 144 | * [[Reconstitution of lyophilised peptides]] |
| + | 145 | * [[Underfilling]] | |
| 143 | 146 | ||
| 144 | {{DEFAULTSORT:Vial}} | 147 | {{DEFAULTSORT:Vial}} |