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Cold chain: difference between revisions

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Revision 25 — 18:18, 12 May 2025
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132'''Last mile.''' Delivery to an unattended address ends the chain at a doorstep. The parcel then experiences the local ambient profile until collected, and no record exists of how long that was.132'''Last mile.''' Delivery to an unattended address ends the chain at a doorstep. The parcel then experiences the local ambient profile until collected, and no record exists of how long that was.
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+134'''Domestic storage.''' Studies of domestic refrigerators used to store insulin and vaccines have repeatedly found substantial fractions operating outside 2–8 °C, with excursions in both directions and with door shelves warmer and rear walls colder than the compartment average.{{r|hanson2017}}
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134== References ==136== References ==
135{{reflist}}137{{reflist}}
149<ref name="ich_q1a">International Council for Harmonisation, ''Q1A(R2): Stability Testing of New Drug Substances and Products'' (2003).</ref>151<ref name="ich_q1a">International Council for Harmonisation, ''Q1A(R2): Stability Testing of New Drug Substances and Products'' (2003).</ref>
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+153== Further reading ==
+154* World Health Organization. ''Technical Supplements to WHO Technical Report Series 961, Annex 9'' (2015) — individually addressed operations including temperature mapping and shipper qualification.
+155* Kartoglu U, Ames H. "Ensuring quality and integrity of vaccines throughout the cold chain: the role of temperature monitoring." ''Human Vaccines and Immunotherapeutics'' (2022).
+156* Bishara RH. "Cold chain management — an essential component of the global pharmaceutical supply chain." ''American Pharmaceutical Review'' 9(1):105–109 (2006).
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151== See also ==158== See also ==
152* [[Temperature excursion]]159* [[Temperature excursion]]
156* [[Beyond-use date]]163* [[Beyond-use date]]
157* [[Vial]]164* [[Vial]]
+165* [[Customs seizure]]
158166
159{{DEFAULTSORT:Cold chain}}167{{DEFAULTSORT:Cold chain}}