Cold chain: difference between revisions
Diff·revision 25 → 26·00:31, 4 Jun 2025
Difference between revision 25 and revision 26 of Cold chain. 7 lines changed; the page grew by 993 bytes.
| Revision 25 — 18:18, 12 May 2025 FmocFrancis (talk) unpipe a link that did not need piping 21,309 bytes +891 | Revision 26 — 00:31, 4 Jun 2025 SupplyWatchSuri (talk) ce per PP:MOS 22,302 bytes +993 | ||
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| 134 | '''Domestic storage.''' Studies of domestic refrigerators used to store insulin and vaccines have repeatedly found substantial fractions operating outside 2–8 °C, with excursions in both directions and with door shelves warmer and rear walls colder than the compartment average.{{r|hanson2017}} | 134 | '''Domestic storage.''' Studies of domestic refrigerators used to store insulin and vaccines have repeatedly found substantial fractions operating outside 2–8 °C, with excursions in both directions and with door shelves warmer and rear walls colder than the compartment average.{{r|hanson2017}} |
| 135 | 135 | ||
| + | 136 | == Distribution outside regulated channels == | |
| + | 137 | A substantial proportion of the material discussed on this wiki moves outside pharmaceutical distribution, and the cold-chain concept applies to it only partially. The differences are structural rather than incidental. | |
| + | 138 | ||
| + | 139 | There is generally no temperature record. Parcels move by ordinary post or courier without loggers, and no party undertakes to maintain a condition. Where a supplier states a storage requirement, it is a recommendation for the recipient rather than a specification the shipment was managed against. | |
| + | 140 | ||
| + | 141 | The product is generally lyophilised, which changes the physics substantially. A dry amorphous solid held below its glass transition temperature degrades orders of magnitude more slowly than the same peptide in solution, and its temperature sensitivity is correspondingly lower. This is the physical basis on which ambient shipment of dry peptide is defensible, and it is set out in detail at [[Lyophilisation]].{{r|ich_q1a}} | |
| + | 142 | ||
| 136 | == References == | 143 | == References == |
| 137 | {{reflist}} | 144 | {{reflist}} |